发明名称 |
Biosensor containing a biochemical substance immobilized on a layer of an olefinic-unsaturated, epoxyfunctional polyether |
摘要 |
A biosensor is prepared having a selective detection system containing a biochemical substance such as an enzyme immobilized by reaction with epoxy groups of an olefinic-unsaturated, epoxyfunctional polyether. Prior to immobilization, the polyether is applied to a carrier and crosslinked by treatment with high-energy radiation or peroxide to form a layer. After reacting the biochemical substance with epoxy groups, non-reacted epoxy groups are reacted with a compound containing an amino group and/or a carboxyl group such as an amino acid. Before immobilizing of the biochemical substance and after crosslinking, the polyether may be hydrophilized by reacting some of the epoxy groups with a hydrophilic compound such as an amino acid.
|
申请公布号 |
US5389534(A) |
申请公布日期 |
1995.02.14 |
申请号 |
US19930035019 |
申请日期 |
1993.03.22 |
申请人 |
SIEMENS AKTIENGESELLSCHAFT |
发明人 |
VON GENTZKOW, WOLFGANG;FEUCHT, HANS-DIETER |
分类号 |
C08G59/02;C07K17/08;C08G59/04;C08L63/10;C12M1/40;C12N11/08;C12Q1/00;G01N27/327;G01N27/414;(IPC1-7):C12N11/08;C12N11/06;G01N33/545 |
主分类号 |
C08G59/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|