NEW COMPOUND AND ITS PREPARATION

摘要

A compound of formula (1) in which R<4> is acyl, R<5> is lower alkyl, R<6> is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic-(lower)alkyl, R<7> is lower alkyl or lower alkylthio(lower)alkyl, R<8> is carboxy or protected carboxy, A is lower alkylene, Z is a group of formula (2) wherein R<1> is hydrogen, lower alkyl, common amino-protective group or optionally substituted ar(lower)alkyl, R<2> is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic-(lower)alkyl, optionally substituted cyclo(lower)alkyl(lower)alkyl, common amino-protective group, amino(or protected amino)(lower)alkyl, optionally substituted heterocyclic-carbonyl or cyclo(lower)alkyl, and R<3> is optionally substituted heterocyclic(lower)alkyl, and m is an integer of 0 to 2, or pharmaceutically acceptable salts thereof, useful as endothelin antagonist.