| 摘要 |
<p>Apparatus and in vivo methods for distinguishing normal and abnormal cervical tissue and detecting cervical intraepithelial neoplasia (CIN) in a diagnostic tissue sample. A source of electromagnetic radiation (36) is applied to the diagnostic cervical tissue sample and the presumptively known normal cervical tissue. Fluorescence intensity spectra induced in the diagnostic tissue sample and the presumptively known tissue by the radiation source is detected by at least one radiation detector (26). A computer (20) is programmed to measure a peak normal fluorescence intensity value in each of the normal fluorescence intensity spectra, to calculate an average peak normal fluorescence intensity from the peak normal fluorescence intensity values, to measure a peak fluorescence intensity value from the fluorescence intensity spectrum induced in the diagnostic tissue sample, to calculate a slope parameter which is indicative of tissue abnormality, to calculate relative peak fluorescence intensity as a function of the peak intensity value, the average peak normal intensity, and to detect tissue abnormality as a function of the slope parameter and the relative peak fluorescence intensity.</p> |
