| 摘要 |
<p>A method of identifying potentially useful treatments which restore the function of CFTR or other related protein mutations is disclosed. The method involves creation of yeast STE6-CFTR chimeric sequences which upon introduction of a desired mutation inhibit expression of the yeast STE6 gene. A yeast assay (STE6Δ) transformed to include the hybrid chimeras is then exposed to a potential treatment for the mutation. A treatment which restores the function of the STE6 gene and thereby allows mating of the yeast strain is indicative of a potential remedial treatment for the mutation in this selected protein.</p> |
