发明名称 |
VACCINATION AND METHODS AGAINST MULTIPLE SCLEROSIS RESULTING FROM PATHOGENIC RESPONSES BY SPECIFIC T CELL POPULATIONS |
摘要 |
The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. The vaccine is administered to the mammal in a manner that induces an immunologically effective response so as to affect the course of the disease. The invention additionally provides specific beta -chain variable regions of the T cell receptor, designated V beta 6.2/3, V beta 6.5, V beta 2, V beta 5.1, V beta 13 and V beta 7, which are central to the pathogenesis of multiple sclerosis (MS). |
申请公布号 |
WO9425063(A1) |
申请公布日期 |
1994.11.10 |
申请号 |
WO1994US04789 |
申请日期 |
1994.04.29 |
申请人 |
THE IMMUNE RESPONSE CORPORATION;SAN DIEGO REGIONAL CANCER CENTER |
发明人 |
BROSTOFF, STEVEN, W.;WILSON, DARCY, B.;SMITH, LAWRENCE, R.;GOLD, DANIEL, P.;CARLO, DENNIS, J. |
分类号 |
A61K39/00;C07K14/725;G01N33/564;G01N33/569;(IPC1-7):A61K39/00;C12Q1/68 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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