发明名称 1,3-dioxane derivatives having protein kinase C inhibitory activity
摘要 The present invention provides compounds having the formula <IMAGE> wherein R1 is alkyl, alkenyl and alkynyl having from 2 to about 20 carbon atoms; R2, R3 and R6 are independently H, phenyl or alkyl having from 1 to about 20 carbon atoms; and R4 and R5 are independently H, R6imino, or amidino, and pharmaceutically acceptable salts thereof which are useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
申请公布号 US5360818(A) 申请公布日期 1994.11.01
申请号 US19930110847 申请日期 1993.08.24
申请人 SPHINX PHARMACEUTICALS CORPORATION 发明人 JIANG, JACK B.;JOHNSON, MARY G.;NICHOLS, JEFFREY
分类号 C07D319/06;(IPC1-7):A61K31/35;C07D309/14 主分类号 C07D319/06
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