INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS

摘要

A compound of formula (I), wherein R<1> is an optionally protected carboxy(lower)alkyl, R<2> is a hydrogen, an optionally substituted aryl or a carboxy, X is a bond, -O-, -NH- or a cycloalkylene, and Y is an alkylene which may be interrupted by an oxygen atom, an alkenylene or an alkadienylene, or a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a testosterone 5 alpha -reductase inhibitor and effective against testosterone 5 alpha -reductase-mediated diseases such as prostatism, prostatic hypertrophy, prostatic cancer, alopecia, hirsutism (e.g. female hirsutism), androgenic alopecia (or male-pattern baldness), acne (e.g. acne vulgaris, pimple), and another hyperandrogenisms.