Peptides, and antidementia agents containing the same

摘要

Disclosed is a novel peptide having one of the formulae: <IMAGE> (A and B are the amino acids: wherein if A is D- or L-Pro, B is Hat or Cit; if A is D-Pro, B is D-Arg, and if B is D- or L-Arg, A is Sat, Pip, Aze or Arg) Asn-A-L- (D-)Pro-Arg- (Gly)n (A is Set, Thr or Ala, n is 1 or 0) A-Ser-Pip-Arg (A is Pro-Asn-, Asn- or Pro-) <IMAGE> (A is cyclopentylcarbonyl, Pro or pGlu; B is Gly or beta -Ala, W is a hydrogen atom or a group having the formula: or a peptide having the formula: <IMAGE> wherein A and B have the same meanings as mentioned above, respectively pGlu-Asn-Ser-A-B-(Gly)n (A is Aze, D- or L-Pro, Pip or Sat, B is D- or L-Arg, Cit, Hat, Lys or Orn, n is 1 or 0) and Pro- (Ash)m-Set-L- (D-)Pro-Arg- (Gly) n (m and n are independently 0 or 1) their functional derivatives, and pharmaceutically acceptable salts thereof.