| 摘要 |
A device enabling one or more active principles or substances to be released in a gradual and programmed manner, wherein the device can be obtained by: a) preparing a powder comprising a resin or polymer matrix in which at least one suitable plasticizer is fully absorbed by heating the plasticizer and hot spraying it onto the matrix while it is being maintained in temperature, thereby saturating the resin with plasticizer; b) cooling the powder obtained in a) to a temperature below 30 DEG C; c) cold mixing the powder obtained in b) with at least 5% of at least one carrier of active principle; then d) adding the active principle(s); and e) suitably forming the powder obtained in d) by any appropriate means, which device releases the active principle uniformly and completely. The device further includes a covering made of a polymer which is impermeable to the active principle(s) and which covers a portion of the surface of the device. A method of preparing the device and applications thereof to preparing medicines suitable for administration per os, to preparing medicines suitable for administration by skin contact, and to preparing antiparasite collars.
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