| 摘要 |
<p>The present invention is directed to peptides representing all or a portion of tyrosine activation motifs (TAMs), as well as analogs and derivatives thereof (collectively termed herein 'TAM Mimics'). In particular, such analogs and derivatives include peptides and hybrid molecules with both peptide and non-peptide portions. In a specific embodiment, a hybrid molecule is provided which contains an amino(N)- or carboxy(C)-terminal non-peptide helix inducer. In another specific embodiment, the hybrid molecule contains an internal non-peptide structure that maintains the helical character of the TAM mimic. TAM Mimics of the invention inhibit the activation of various cells with immune system function. Therapeutic methods based on the immune function inhibitory activity of the TAM Mimics, as well as pharmaceutical compositions, are also provided. In a preferred embodiment of the invention, TAM Mimics are formulated for pulmonary administration; thus, for example, the invention provides inhalers containing compositions comprising a therapeutically or prophylactically effective amount of a TAM Mimic.</p> |
