| 摘要 |
A therapeutically-useful conjugate comprises an alginate polymeric carrier and a therapeutically-active bioactive agent connected covalently via a biodegradable spacer linkage interposed therebetween which enables the bioactive agent to be progressively released, under predetermined environmental conditions, following administration to a mammal in the course of therapy. The conjugate is effective for delivering bioactive agents to targets existing in low-pH environments, either at the target surface or in the target interior. |
