发明名称 |
ANTISENSE MOLECULES DIRECTED AGAINST GENES OF THE RAF ONCOGENE FAMILY |
摘要 |
The present invention is directed to a polynucleotide, of about 10 to about 50 nucleic acid bases in length, which hybridizes to the gene encoding raf. The present invention is also directed to a pharmaceutical composition comprising the above polynucleotide dissolved or dispersed in a physiologically tolerable diluent. The present invention is further directed to a process for inhibiting vascular smooth muscle cell proliferation, a process for treating vascular smooth muscle cell proliferation, and process for treating a disease state involving smooth muscle cell proliferation. These processes comprise contacting the vascular smooth muscle cells or administering to a host mammal in need of such treatment, an effective amount of a polynucleotide of about 10 to about 50 nucleic acid bases in length, said polynucleotide hybridizing to the gene for raf. |
申请公布号 |
WO9415645(A1) |
申请公布日期 |
1994.07.21 |
申请号 |
WO1993US12603 |
申请日期 |
1993.12.28 |
申请人 |
TEXAS BIOTECHNOLOGY CORPORATION |
发明人 |
DENNER, LARRY, A.;REGE, AJAY, A.;DIXON, RICHARD, A., F. |
分类号 |
C07H21/00;C12N15/113;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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