| 发明名称 |
CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS |
| 摘要 |
This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
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| 申请公布号 |
CA2152912(A1) |
申请公布日期 |
1994.07.07 |
| 申请号 |
CA19932152912 |
申请日期 |
1993.12.29 |
| 申请人 |
RHONE-POULENC RORER PHARMACEUTICALS INC. |
发明人 |
ULLRICH, JOHN W.;KIESOW, TERENCE J.;NEUENSCHWANDER, KENT W.;SCOTESE, ANTHONY C.;LEARN, KEITH S.;DANKULICH, WILLIAM P. |
| 分类号 |
C07D317/58;A61K31/135;A61K31/335;A61K31/34;A61K31/343;A61K31/35;A61K31/352;A61K31/357;A61K31/36;A61K31/38;A61K31/381;A61K31/40;A61K31/403;A61K31/404;A61K31/42;A61K31/423;A61K31/425;A61K31/428;A61K31/47;A61P3/08;A61P9/10;A61P43/00;C07C217/52;C07C317/26;C07C323/23;C07D209/12;C07D215/14;C07D263/56;C07D263/57;C07D277/66;C07D307/79;C07D307/80;C07D311/58;C07D319/20;C07D333/54;(IPC1-7):C07D263/57;C07D209/14;C07C225/20;A61K31/33;C07D333/58;C07D307/81 |
主分类号 |
C07D317/58 |
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