发明名称 |
LYMPHOTOXIN- beta , LYMPHOTOXIN- beta COMPLEXES, PHARMACEUTICAL PREPARATIONS AND THERAPEUTIC USES THEREOF |
摘要 |
This invention relates to lymphotoxin- beta , a lymphocyte membrane type protein. This protein is found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23.D7 cells. This invention also relates to complexes formed between lymphotoxin- beta and other peptides such as lymphotoxin- alpha and to complexes comprising multiple subunits of lymphotoxin- beta . These proteins and complexes are useful in holding LT- alpha formed within the cell on the cell surface where the LT- alpha /LT- beta complex may act as an inflammation regulating agent, a tumor growth inhibiting agent, a T cell inhibiting agent, a T cell activating agent, an autoimmune disease regulating agent, or an HIV inhibiting agent. Furthermore, the antitumor activity of the LT- alpha /LT- beta complex may be delivered to tumor cells by tumor infiltrating lymphocytes (TILs) transfected with the gene for LT- beta . |
申请公布号 |
WO9413808(A2) |
申请公布日期 |
1994.06.23 |
申请号 |
WO1993US11669 |
申请日期 |
1993.12.02 |
申请人 |
BIOGEN, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BROWNING, JEFFREY;WARE, CARL, F. |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P29/00;A61P31/12;A61P31/18;A61P35/00;A61P37/02;A61P37/06;A61P43/00;C07H21/04;C07K14/47;C07K14/525;C07K14/715;C07K19/00;C12N5/10;C12N15/19;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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