发明名称 Pyrimidine nucleoside derivative and antiviral agent containing the derivative as active ingredient
摘要 A pyrimidine nucleoside derivative and pharmaceutically acceptable salt thereof specified by the presence of ethyl group or isopropyl group at 5-position of the pyrimidine ring and the presence of a (substituted) phenylthio or a (substituted) benzyl group at 6-position of the pyrimidine ring is provided. The pyrimidine nucleoside derivative and pharmaceutically acceptable salt thereof show a markedly higher anti-retroviral activity than conventional analogous compounds and have a relatively low toxicity against the host cells, and therefore, are useful as an active ingredient of antiviral agent.
申请公布号 US5318972(A) 申请公布日期 1994.06.07
申请号 US19910676912 申请日期 1991.03.28
申请人 MITSUBISHI KASEI CORPORATION 发明人 MIYASAKA, TADASHI;TANAKA, HIROMICHI;DE CLERCQ, ERIK D. A.;BABA, MASANORI;WALKER, RICHARD T.;UBASAWA, MASARU
分类号 C07D239/54;C07D239/56;C07D239/58;C07D239/60;(IPC1-7):A61K31/505;C07D239/10 主分类号 C07D239/54
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