发明名称 |
Pyrimidine nucleoside derivative and antiviral agent containing the derivative as active ingredient |
摘要 |
A pyrimidine nucleoside derivative and pharmaceutically acceptable salt thereof specified by the presence of ethyl group or isopropyl group at 5-position of the pyrimidine ring and the presence of a (substituted) phenylthio or a (substituted) benzyl group at 6-position of the pyrimidine ring is provided. The pyrimidine nucleoside derivative and pharmaceutically acceptable salt thereof show a markedly higher anti-retroviral activity than conventional analogous compounds and have a relatively low toxicity against the host cells, and therefore, are useful as an active ingredient of antiviral agent.
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申请公布号 |
US5318972(A) |
申请公布日期 |
1994.06.07 |
申请号 |
US19910676912 |
申请日期 |
1991.03.28 |
申请人 |
MITSUBISHI KASEI CORPORATION |
发明人 |
MIYASAKA, TADASHI;TANAKA, HIROMICHI;DE CLERCQ, ERIK D. A.;BABA, MASANORI;WALKER, RICHARD T.;UBASAWA, MASARU |
分类号 |
C07D239/54;C07D239/56;C07D239/58;C07D239/60;(IPC1-7):A61K31/505;C07D239/10 |
主分类号 |
C07D239/54 |
代理机构 |
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代理人 |
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地址 |
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