UNLÖSLICHE SALZE VON LANTHANIDEN ZUR BILDLICHEN DARSTELLUNG DES MAGEN-DARMTRAKTS MITTELS NUKLEARMAGNETISCHER RESONANZ.

摘要

PCT No. PCT/EP91/00679 Sec. 371 Date Nov. 6, 1992 Sec. 102(e) Date Nov. 6, 1992 PCT Filed Apr. 9, 1991 PCT Pub. No. WO91/16079 PCT Pub. Date Oct. 31, 1991.Diagnostic compositions particularly useful for NMR imaging of the gastrointestinal tract, comprise physiologically acceptable aqueous suspensions of insoluble salts of lanthanides, buffered, if required, at a pH value between 6.0 and 8.5 and which are, if required, formulated with appropriate insoluble organic or inorganic additives and/or with dispersing agents, suspending agents or viscosity-enhancing agents. These compositions are capable of increasing the value of the r2/r1 ratio, in which r1 and r2 are the longitudinal and transversal relaxivities of the protons of the surrounding water, thus permittting the production of clear images which have negative contrast and which lack artefacts of metallic type.