PEPTIDE INHIBITORS OF CELLULAR ADHESION

摘要

Novel cyclic peptides of the selectin 54-63 sequence exhibit unexpected and desired properties. Specific points of cyclization or conformational restriction in conjunction with specific substitutions have been identified that not only unexpectedly enhance the biological activity of these compounds, but also significantly increase their resistance to enzymatic degradation. Formulas of the active compounds and representative examples of preferred peptides are presented herein.