| 摘要 |
The present invention relates to a monoclonal antibody which specifically recognizes 6,15-diketo-13,14-dihydro-prostaglandin F1(alpha) with high sensitivity, a hybridoma producing said monoclonal antibody, a method of establishing said hybridoma and an immunoassay method for 6,15-diketo-13,14-dihydro-prostaglandin F1(alpha) using said monoclonal antibody. The monoclonal antibody of the present invention makes it possible to conveniently measure 6,15-diketo-13,14-dihydro-prostaglandin F1(alpha), a stable metabolite of prostaglandin I2 thought of as reflecting the concentration changes therein, with specificity and high sensitivity. It is useful in determining the content of prostaglandin I2, which exhibits platelet aggregating inhibitory activity, vasodilating activity and other activities, in biological samples.
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