发明名称 |
Séquence d'acide nucléique hybride, mammifères transgéniques non-humains possédant une telle séquence et leurs applications ainsi que méthode de production desdits mammifères. |
摘要 |
Hybrid nucleic acid sequence comprising a sequence coding for a human membrane receptor involved in the regulation of the sinusal rate of heart-beat and particularly the beta 1-adrenergic receptor, non-human transgenic mammals having such sequence and applications thereof as research model, method for producing such mammals, cells and tissues of non-human transgenic mammals wherein the expression of said human receptor is controlled as well as method for valuation of drugs useful for treating heart-beat rate troubles. Said sequence is comprised at least of one fragment of a gene coding for a human membrane receptor involved in the regulation of the human sinusal heart-beat rate and a heterologous promoter specific to the auricles.
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申请公布号 |
FR2694765(A1) |
申请公布日期 |
1994.02.18 |
申请号 |
FR19920009946 |
申请日期 |
1992.08.12 |
申请人 |
INSTITUT NAL SANTE RECHERC MEDIC;CENTRE NAL RECHERC SCIENTIFIQUE |
发明人 |
BERTIN BRIGITTE;BRIAND PASCALE;STROSBERG ARTHUR DONNY;SWYNGHEDAUW BERNARD |
分类号 |
C07K14/705;C12N15/12;C12N15/85;(IPC1-7):C12N15/12;C12N5/06;A01K67/02;A01K67/027;G01N33/50 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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