发明名称 |
Intercellular adhesion molecules, and their binding ligands |
摘要 |
Pharmaceutical compositions comprising antibodies to intercellular adhesion molecule-1 (ICAM-1 or CD54) are useful in methods of decreasing the severity of inflammation associated with the adhesion of leukocytes to cells bearing ICAM-1. Treatment with anti-ICAM-1 antibodies reduced the severity of inflammation associated with acute organ or tissue rejection and prolonged allograft survival time. Such compositions may optionally contain other immunsuppressive agents. |
申请公布号 |
US5284931(A) |
申请公布日期 |
1994.02.08 |
申请号 |
US19900515478 |
申请日期 |
1990.04.27 |
申请人 |
DANA FARBER CANCER INSTITUTE |
发明人 |
SPRINGER, TIMOTHY A.;ROTHLEIN, ROBERT;MARLIN, STEVEN D.;DUSTIN, MICHAEL L. |
分类号 |
A61K38/00;A61K38/17;A61K39/00;C07K14/705;C07K16/28;C12N15/12;G01N33/574;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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