| 摘要 |
The present invention provides a synthetic FIV polypeptide comprising an amino acid sequence substantially corresponding to all or a portion of the FIV envelope protein, or an antigenic fragment or functionally-equivalent variant thereof, in which the proteolytic cleavage site between the transmembrane and surface polypeptides of the native FIV envelope precursor protein has been eliminated and which comprises at least a portion of a transmembrane polypeptide and at least a portion of a surface polypeptide. Also provided are nucleic acid molecules encoding such polypeptides, methods for their recombinant expression, vaccine compositions containing them, and their use in combatting FIV. |
