| 发明名称 |
HYBRID OLIGONUCLEOTIDE PHOSPHOROTHIOATES |
| 摘要 |
2140649 9402498 PCTABS00030 The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
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| 申请公布号 |
CA2140649(A1) |
申请公布日期 |
1994.02.03 |
| 申请号 |
CA19932140649 |
申请日期 |
1993.07.22 |
| 申请人 |
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发明人 |
METELEV, VALERI;AGRAWAL, SUDHIR |
| 分类号 |
C12N15/09;A61K31/70;A61K31/7088;A61K31/713;A61K48/00;A61P9/10;A61P9/12;A61P29/00;A61P31/04;A61P31/12;A61P33/02;A61P35/00;C07H21/00;C07H21/02;C07H21/04;C12N15/113;C12Q1/68;(IPC1-7):C07H21/00 |
主分类号 |
C12N15/09 |
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代理人 |
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