| 摘要 |
Substituted phenylcarbamates and ureas of formula (I) wherein R<1> represents a hydrogen or a halogen atom, or a C1-6alkyl, C1-6alkoxy or hydroxy group; R<2> represents an oxadiazole or thiadiazole ring substituted by a group selected from C1-6alkyl, C3-7cycloalkyl, -CH2C2-5alkenyl, -CH2C2-5alkynyl, phenyl or benzyl; X represents NH or an oxygen atom; m represents 0, 1 or 2; R<3> represents C1-6alkyl, benzyl, -(CH2)nR<4> or (a); R<4> represents a group selected from cyano, hydroxyl, C1-6alkoxy, phenoxy, C(0)C1-6alkyl, C(0)C6H5, -CONR<6>R<7>, -NR<6>COR<7>, -SO2NR<6>R<7> or -NR<6>SO2R<7> (wherein each of R<6> and R<7> independently represent a hydrogen atom, a C1-6alkyl or phenyl group); n represents 2 or 3; R<5> represents COR<8> or SO2R<8> (wherein R<8> represents a hydrogen atom, a C1-6alkyl or phenyl group); and quaternary ammonium derivatives, piperidine N-oxides and pharmaceutically acceptable salts and solvates thereof; which compounds are potent and specific antagonists of 5-hydroxytryptamine (5HT; seretonin). |
