发明名称 |
MN GENE AND PROTEIN |
摘要 |
A new gene -- MN -- and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and fusion proteins are provided. Expression of the MN gene is disclosed as being associated with tumorigenicity, and the invention concerns methods and compositions for detecting and/or quantitating MN antigen and/or MN-specific antibodies in vertebrate samples that are diagnostic/prognostic for neoplastic and pre-neoplastic disease. Test kits embodying the immunoassays of this invention are provided. MN-specific antibodies are disclosed that can be used diagnostically/prognostically, therapeutically, for imaging, and for affinity purification of MN proteins/polypeptides. Also provided are nucleic acid probes for the MN gene as well as test kits comprising said probes. The invention also concerns vaccines comprising MN proteins/polypeptides which are effective to immunize a vertebrate against neoplastic diseases associated with the expression of MN proteins. The invention still further concerns antisense nucleic acid sequences that can be used to inhibit MN gene expression. |
申请公布号 |
WO9318152(A1) |
申请公布日期 |
1993.09.16 |
申请号 |
WO1993US02024 |
申请日期 |
1993.03.08 |
申请人 |
CIBA CORNING DIAGNOSTICS CORP.;INSTITUTE OF VIROLOGY |
发明人 |
ZAVADA, JAN;PASTOREKOVA, SILVIA;PASTOREK, JAROMIR |
分类号 |
G01N33/53;A61K39/00;A61K39/12;A61K39/395;A61K51/00;A61P35/00;C07K14/47;C07K14/82;C07K16/00;C07K16/08;C07K16/18;C12N1/20;C12N5/10;C12N15/02;C12N15/09;C12N15/12;C12N15/33;C12N15/62;C12P21/02;C12P21/08;C12R1/91;G01N33/569 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|