PHARMACEUTICAL PREPARATIONS

摘要

A pharmaceutical preparation is disclosed which is made up of a micelle consisting of a cationic tenside with a monovalent anion and a hydrophobic pharmaceutical active substance or agent dispersed in a solvent whose pH value is < 7.0, the critical micellization concentration (cmc) lying in the range of 1.0 . 10-7 to 1.5 . 10-4 mol/liter. In addition a number of novel cationic tensides (heterocycles) is disclosed. The preparations disclosed have in particular the advantage that by increasing the hydrophobicity of the alkyl or aryl chain or radical at the N+ tenside the membrane permeability is increased so that the pharmaceutical active substances can enter quantitatively and passively into the cytosol.