TRIPLE-HELIX FORMATION AT (PUNPYN).(PUNPYN) TRACTS

摘要

An oligonucleotide capable of forming a triple-helix with a nucleic acid molecule containing a target nucleic acid sequence is described, where the oligonucleotide is comprised of tandem, alternating tracts of purine and pyrimidine sequences, and where the oligonucleotide is effective to form a triple-helix structure with a target nucleic acid sequence having alternating tracts of purine and pyrimidine sequences. A method of cleaving the nucleic acid molecule is also described.