| 摘要 |
The present invention relates to novel isomers of 6,9 alpha -nitrilo-PGI1s having a specific steric configuration, which are replaced by an alkyl (C1 to C8)-substituted cycloalkyl (C4 to C7) group in (1S,S) form, in (1S,R) form or in cis form at the 15-, 16- or 17-position of the PG skeleton, and, alkyl esters thereof, non-toxic salts thereof, non-toxic acid addition salts thereof and cyclodextrin clathrates thereof, possessing more potent PG-like pharmacological activity than other isomers.
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