TETRAHYDRONAPHTHALENE DERIVATIVES

摘要

It has been found that the novel tetrahydronaphthaiene derivatives of the formula I wherein the symbols A, X, n. R, R1 R2 and R3 have the significance given in claim 1. have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pactoris, ischaemia, arrhythmias. high blood pressure and cardiac insufficiency. The compounds of formula I can be manufactured by aminating a compound of the formula II with a corresponding N-alkylamine and optional subsequent O-acylation or reaction with an isocyanate and N-oxidation.