发明名称 |
MULTIPLE SCLEROSIS T-CELL RECEPTOR |
摘要 |
<p>This invention is directed to therapeutic agents comprising peptides in turn comprising a portion of the T-cell manifested in multiple sclerosis. Embodiments of the invention include peptides, vaccines, receptors and entire (attenuated) T-cells. This invention is also directed to methods using the foregoing agents to suppress immune response against myelin basic protein, and/or to suppress T-cells that recognize an immunodominant epitope of human myelin basic protein. Additionally, this invention is directed to diagnostic methods and kits for diagnosing multiple sclerosis.</p> |
申请公布号 |
EP0522091(A4) |
申请公布日期 |
1993.05.26 |
申请号 |
EP19910910085 |
申请日期 |
1991.03.29 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL;AUTOIMMUNE, INC. |
发明人 |
WUCHERPFENNING, KAI, W.;WEINER, HOWARD, L.;HAFLER, DAVID, ALLEN |
分类号 |
A61K38/00;A61K38/11;A61K38/17;A61K39/00;A61P25/00;A61P37/06;C07K7/06;C07K7/08;C07K14/725;C12N5/08;C12N5/10;C12N15/09;C12Q1/68;G01N33/53;(IPC1-7):A61K37/02;C12N5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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