| 发明名称 |
Substituted salicylic acids. |
| 摘要 |
A compound of the formula Het-NR-SO2-Ph2-A-Ph1(COOH)(OH) and tautomic form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases. |
| 申请公布号 |
ZA9208864(B) |
申请公布日期 |
1993.05.13 |
| 申请号 |
ZA19920008864 |
申请日期 |
1992.11.17 |
| 申请人 |
KABI PHAMACIA AB. |
发明人 |
HUBERT AGBACK;LEIF AHRGREN;THOMAS BERGLINDH;MARTIN HARALDSSON;LARS-INGE OLSSON;GORAN SMEDEGARD |
| 分类号 |
A61K31/41;A61K31/415;A61K31/42;A61K31/421;A61K31/426;A61K31/428;A61K31/44;A61K31/4402;A61K31/4418;A61K31/495;A61K31/496;A61K31/4965;A61K31/50;A61K31/505;A61K31/603;A61P1/00;A61P29/00;A61P37/02;A61P37/06;C07D213/75;C07D213/76;C07D213/78;C07D233/88;C07D233/90;C07D237/20;C07D239/42;C07D239/69;C07D241/20;C07D249/12;C07D249/14;C07D261/14;C07D261/16;C07D263/28;C07D277/20;C07D277/22;C07D277/32;C07D277/38;C07D277/82 |
主分类号 |
A61K31/41 |
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