| 摘要 |
A series of polyribonucleotides containing methyl and/or sulphur substitutions such as poly(1-methyl-6-thioinosinic acid) also [poly(m<1>s<6>I)], poly(1-methyl-6-thioguanylic) acid [poly(m<1>s<6>G)], and poly(6-thioguanylic acid) complexed with polycytidylic acid [poly(s<6>G)-poly(C)] are useful in treating human cells infected with AIDS viruses or viral opportunistic pathogens by inhibiting the virus from developing or spreading to unaffected cells. Poly(m<1>s<6>I), poly(m<1>s<6>G), and poly(s<6>G)-poly(C) may be administered orally, parenterally or transdermally per se or in the form of a pharmaceutically acceptable salt. As regarding the AIDS virus, these agents function in one or more ways as inhibitors of the viral reverse transcriptase necessary for viral replication, and/or also block the formation of syncytia (giant cells) which are characteristic of HIV infection and facilitate the transmission of the virus to uninfected cells. |
