Anti-human milk fat globule humanised antibodies.

摘要

Humanised antibody molecules (HAMs) are described having specificity for human milk fat globule and having an antigen binding site wherein at least one of the complementarity determining regions (CDRs) of the variable domains is derived from the mouse monoclonal antibody CTMO1 and the remaining immunoglobulin-derived parts of the HAM are derived from a human immunoglobulin. The HAMs may be chimeric humanised antibodies or CDR-grafted humanised antibodies and are preferably produced by recombinant DNA techniques. The HAMs may be conjugated to an effector or reporter molecule, particularly methyltrithio anti-tumour agents, and are useful for in vivo diagnosis and therapy.