发明名称 NOVEL ALKOXY SUBSTITUTED TAXANES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
摘要 <p>A taxane derivative of the formula <CHEM> wherein R<5> is phenyl or substituted phenyl, R<7> is CH<7>O-, or CH<7>CH<6>O-, Z is -OT<5>, T<5> is hydrogen, hydroxyl protecting group, or -COT<6>, T<6> is H, C<5>-C1/4 alkyl, C<5>-C1/4 alkenyl, C<5>-C1/4 alkynyl or monocylic aryl, Ac is acetyl, and E<5> and E<6> are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.</p>
申请公布号 AU2212392(A) 申请公布日期 1993.03.25
申请号 AU19920022123 申请日期 1992.09.04
申请人 FLORIDA STATE UNIVERSITY 发明人 ROBERT A. HOLTON;RONALD J. BEIDIGER
分类号 A61K31/335;A61K31/337;A61P35/00;C07D305/14;C07D407/12;C07D409/12;C07F7/00;C07F7/18;C08G67/00 主分类号 A61K31/335
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