| 摘要 |
<p>A DNA sequence encoding human β-casein (a human milk protein) and analogues of said DNA sequence which encodes a polypeptide having the calcium binding activity of human β-casein or opioid activity or angiotension converting enzyme (ACE) inhibitory activity. The polypeptide encoded by said DNA sequence or analogues may be used in the production of recombinant human β-casein either by means of a prokaryotic or an eukaryotic production system, or more advantageously by means of production in transgenic non-human mammals such as cows. The recombinant human β-casein is a useful constituent of infant formulae used for feeding infants as a substitute for human milk, i.e. maternal milk. The recombinant human β-casein makes it possible to prepare an infant formula having a closer similarity to human milk and thus an improved nutritional and biological value.</p> |
