发明名称 |
IMMUNOGLOBULIN VARIANTS FOR SPECIFIC FC EPSILON RECEPTORS |
摘要 |
Two classes of polypeptides derived from human IgE are described. One class binds selectively to the high affinity IgE receptor on mast cells and basophils, but not to the low affinity IgE receptor on B-cells, monocytes, eosinophils and platelets. The other class binds to the low affinity receptor, but not the high affinity receptor. The differential binding polypeptides of this invention are useful in diagnostic procedures for IgE receptors or in the therapy of IgE-mediated disorders such as allergies. They also are useful in preparing antibodies capable of binding regions of IgE that participate in receptor binding. |
申请公布号 |
WO9304173(A1) |
申请公布日期 |
1993.03.04 |
申请号 |
WO1992US06860 |
申请日期 |
1992.08.14 |
申请人 |
GENENTECH, INC. |
发明人 |
JARDIEU, PAULA, M.;PRESTA, LEONARD, G. |
分类号 |
A61K39/395;A61K38/00;A61K38/16;A61P37/08;C07K14/00;C07K14/46;C07K16/00;C07K16/18;C07K16/28;C07K16/32;C07K16/42;C07K16/46;C07K19/00;C12N15/02;C12N15/12;C12N15/13;C12P21/08;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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