发明名称 |
PROCESS FOR PURIFYING PENTOSTATIN |
摘要 |
A process for purifying pentostatin from a crude fermentation beer comprising the steps of 1) applying the fermentation beer to a strong cation exchange resin; 2) eluting with ammonium hydroxide; 3) concentrating the eluate; 4) applying the concentrated eluate to a strongly basic anion exchange resin charged with borate ion; 5) eluting with water; 6) applying this eluate to styrene-divinylbenzene beads prewashed with ethanol; 7) eluting the beads with water; and 8) recrysllyzing the pentostatin from water and methanol to yield a product that is greater than 99.7% pure. |
申请公布号 |
AU2381792(A) |
申请公布日期 |
1993.03.02 |
申请号 |
AU19920023817 |
申请日期 |
1992.07.16 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
JAMES CLARK FRENCH;PETER MCDONNELL;HOWARD DANIEL HOLLIS SHOWALTER;COLIN RATH EDMUNDS |
分类号 |
B01J41/20;A61K31/44;A61K31/65;A61K38/05;C07H1/08;C07H19/052;C07H19/23 |
主分类号 |
B01J41/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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