摘要 |
The present invention is directed to novel antibiotic A 40926 derivatives characterized by having a carboxy, (C1-C4)alkoxy- carbonyl, aminocarbonyl, (C1-C4)alkylaminocarbonyl, di(C1- C4)alkylaminocarbonyl or hydroxymethyl substituent on the N-acylaminoglucuronyl moiety and a hydroxy or a polyamine substituent in position 63 of the molecule. The compounds of the invention show high in vitro activity against glycopeptide resistant Enterococci and Staphylococci.
|