发明名称 (OMEGA-(4-(2-PYRIMIDINYL)-1-PIPERAZINYL)ALKYL)-1H-AZOLE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF COGNITIVE FUNCTIONS
摘要 The present invention relates to the use of the derivatives of general formula I <IMAGE> (I) in which: n can have values 1 to 6, and R represents a hydrogen atom, a halogen, a C1 to C4 lower alkyl radical, a heteroaryl radical, a sulpho radical, an N-substituted or N,N-disubstituted sulphamoyl radical, a nitro radical, a hydroxyl radical, an oxo radical, a C1 to C4 lower alkoxy radical, a cyano radical, a C1 to C4 lower alkylcarboxylate radical, an aryl or substituted aryl radical, or an amino or substituted amino radical of formula <IMAGE> in which R1 and R2, which may be identical or different, represent a hydrogen atom, an alkyl radical, an aryl radical, an alkylcarbonyl radical, an arylcarbonyl radical, an alkylsulphonyl radical or an arylsulphonyl radical, the alkyl fragments of these radicals containing from 1 to 4 carbon atoms, and their therapeutically acceptable salts, for the manufacture of medicinal products intended for the treatment of disorders of cognitive funciton, such as presenile dementia, senile dementia, memory dysfunctions, deterioration of awareness and Alzheimer's disease.
申请公布号 US5182281(A) 申请公布日期 1993.01.26
申请号 US19920824995 申请日期 1992.01.24
申请人 LABORATORIOS DEL DR. ESTEVE, S.A. 发明人 FRIGOLA-CONSTANSA, JORDI;PARES-COROMINAS, JUAN
分类号 A61K31/505;A61K9/20;A61K9/48;A61K31/496;A61K31/506;A61P25/28;C07D403/12;C07D403/14;C07D513/04;C07D521/00 主分类号 A61K31/505
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