发明名称 |
AMINOPHENOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF |
摘要 |
<p>Aminophenol derivatives of the following formula (I) (I) wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R8 is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.</p> |
申请公布号 |
CA2065526(A1) |
申请公布日期 |
1992.10.09 |
申请号 |
CA19922065526 |
申请日期 |
1992.04.07 |
申请人 |
GREEN CROSS CORPORATION (THE) |
发明人 |
SUGIYAMA, NAOKI;AKABOSHI, FUMIHIKO;YAKUMARU, HARUKO;GOTO, TOMOKAZU;SUGIURA, MASANORI;KUWAHARA, SHIGEKI;KAJII, MASAHIKO;TANAKA, YOSHIKO;KONDOH, TAKAO;FUKAYA, CHIKARA |
分类号 |
A61K31/135;A61K31/445;A61K31/495;A61K31/695;A61P29/00;A61P37/08;C07C215/76;C07C215/80;C07C217/76;C07C217/82;C07D211/14;C07D211/22;C07D211/46;C07D213/64;C07D213/74;C07D241/18;C07D279/24;C07D295/12;C07D295/13;C07D295/135;(IPC1-7):C07D295/135;C07D279/26;C07D213/38;A61K31/44;A61K31/54;A61K31/55;C07D243/08;C07D401/02;C07D513/04 |
主分类号 |
A61K31/135 |
代理机构 |
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