发明名称 |
Guluronic acid polymers and use of same for inhibition of cytokine production. |
摘要 |
<p>A family of compounds effective in inhibiting interleukin-1 (IL-1 ) production, interleukin-6 (IL-6), tumor necrosis factor (TNF) production, and the production of other leukocyte derived cytokines is comprised of oligomers and polymers of alpha 1-4 linked L-guluronic acid residues which may be administered to a human or mammal in an amount sufficient to inhibit the production effect of leukocyte-derived cytokines. The inhibition of IL-1, IL-6 and TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.</p> |
申请公布号 |
EP0506325(A1) |
申请公布日期 |
1992.09.30 |
申请号 |
EP19920302498 |
申请日期 |
1992.03.24 |
申请人 |
PRONOVA BIOPOLYMER AS;NOBIPOL, NOBIPOLS FORSKNINGSSTIFTELSE |
发明人 |
OTTERLEI, MARIT;ESPEVIK, TERJE;SKJAK-BRAEK, GUDMUND;SMIDSROD, OLAV |
分类号 |
A61K31/70;A61K31/715;A61P7/00;A61P9/00;A61P31/04;C08B37/00 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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