| 摘要 |
Animal derived cells, especially erythrocytes, have been artificially modified (and referred to as engineered erythrocytes or RBCs) so as to incorporate in their plasma membranes an antigen, CD4 protein derived from lymphocytes, which will cause them to selectively seek out and fuse with other cells that are infected with a virus, especially the AIDS virus. These modified cells can be further altered so as to contain in their cytoplasm a cytotoxic agent which, after the cell has fused with a target cell, will result in the pooling of their respective cytoplasms and the death of both cells, with subsequent removal by the reticuloendothelial system. The invention also includes the production and use of similarly modified liposomes. The present invention can be used as a treatment of Acquired Immune Deficiency Syndrome (AIDS). |
