BIFUNKTIONELLE PROTEINE.

摘要

The use of a bifunctional protein (I) consisting of biologically-active interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating factor (CSF) portions as a pharmaceutical is new. (I) in which the two biologically active fragments are joined by a bridge of 1-20 genetically codable amino acids are new. The bridge is pref. of formula -Asp-(AA)x-Pro-, where x = 1-18 and each AA is a genetically codable amino acid other than Cys. Esp. (As)x is Pro-Met-Ile-Thr -Thr-Tyr-Ala -Asp-Asp or Pro-Met-Ile -Thr-Thr-Tyr- Leu-Glu-Glu-Leu-Thr-Ile-Asp-Asp. In (I), the IL-2 and CSF portions are the N-and C-terminal fragments, respectively.