THYMIDINKINASE-DELETIONSMUTANTEN VON BOVINEM HERPESVIRUS-1, DIESE ENTHALTENDE IMPFSTOFFE GEGEN BOVINE RHINOTRACHEITIS UND VERFAHREN ZU DEREN HERSTELLUNG UND VERWENDUNG.
摘要
<p>Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.</p>
申请公布号
DE3684255(D1)
申请公布日期
1992.04.16
申请号
DE19863684255
申请日期
1986.11.07
申请人
NOVAGENE LTD.;BAYLOR COLLEGE OF MEDICINE, HOUSTON, TEX., US