发明名称 |
APROTININ ANALOGUES |
摘要 |
An aprotinin analogue with reduced nephrotoxicity, wherein, to provide a reduced positive net charge, at least one positively charged amino acid residue outside the protease-binding site is removed or replaced with a neutral or negatively charged amino acid residue, and/or wherein at least one negatively charged amino acid residue is inserted or added, and/or wherein at least one neutral amino acid residue is replaced with a negatively charged amino acid residue, and/or wherein, to provide reduced stability, one or more amino acid residues are deleted, added or replaced with one or more other amino acid residues. |
申请公布号 |
WO9206111(A1) |
申请公布日期 |
1992.04.16 |
申请号 |
WO1991DK00299 |
申请日期 |
1991.10.01 |
申请人 |
NOVO NORDISK A/S |
发明人 |
BJOERN, SOEREN, ERIK;NORRIS, KJELD;DINESS, VIGGO;NOERSKOV-LAURITSEN, LEIF;CHRISTENSEN, NIELS, DYHR;BREGENGAARD, CLAUS |
分类号 |
A61K38/55;A61K38/00;A61K38/57;C07K7/00;C07K14/81;C12N1/19;C12N5/10;C12N15/09;C12N15/12;C12N15/15;C12N15/63;C12N15/81;C12P21/02;C12R1/865 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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