T-CELL EPITOPES

摘要

T-cell epitopes of or derived from the TraT protein of E. coli have been identified and used in the preparation of complexes with immunogens to enhance or provide immune responses to the immunogens. The complexes can be prepared either directly, by chemical linkage or as fusion proteins. Where the complexes are prepared as fusion proteins the invention provides for polynucleotides encoding the fusion proteins as well as transformant hosts capable of expressing the fusion proteins. The fusion proteins may be expressed either intracellularly or exported to and expressed on the surface of the transformant host.