| 摘要 |
PURPOSE:To obtain the subject derivative useful as a synthetic raw material for pharmaceuticals and agricultural chemicals in high efficiency from any kind of R,S-mandelonitrile derivatives by treating an R,S-mandelonitrile derivative with a specific microorganism in an aqueous medium. CONSTITUTION:The objective derivative of formula III can be produced by treating an R,S-mandelonitrile derivative or a mixture of benzaldehyde of formula II and hydrocyanic acid in a nearly neutral or basic aqueous medium with a microbial strain belonging to genus Aureobacterium, Pseudomonas, Caseobacter, Alcaligenes, Acinetobacter, Brevibacterium or Nocardia and capable of stereo-selectively hydrolyzing the nitrile group of an R,S-mandelonitrile derivative of formula I (X is substituent at o-, m- or p-site; the substituent is halogen, hydroxy, etc.) or treated product of the bacterial cell. |
