VERFAHREN ZUR HERSTELLUNG VON 1-CHLOR-2-(1-CHLOR-CYCLOPROPYL)-3-(2-CHLOR-PHENYL)-PROPAN-2-OL UND/ODER 2-(1-CHLOR-CYCLOPROPYL)-2-(2-CHLOR-BENZYL)-OXIRAN

摘要

A novel process can be used for the preparation of 1-chloro-2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-propan-2-ol and/or 2-(1-chlorocyclopropyl)-2-(2-chloro-benzyl)-oxirane, by … …  a) reacting 2-chloro-benzyl chloride with comminuted magnesium, optionally in the presence of a catalyst, in the presence of a mixture of toluene and tetrahydrofuran in which the toluene/tetrahydrofuran ratio is between 65:35 and 95:5 parts by weight, at temperatures between 0 DEG C and 100 DEG C, where the 2-chloro-benzyl chloride/ tetrahydrofuran ratio is such that between 1 and 3 moles of tetrahydrofuran are present per mole of 2-chloro-benzyl chloride, subsequently, if appropriate, removing any magnesium which may still be present, and …  b) reacting the Grignard reagent formed with 1-chloro-1-chloroacetyl-cyclopropane in the presence of a mixture of toluene and tetrahydrofuran in which the toluene/tetrahydrofuran ratio is between 65:35 and 95:5 parts by weight, and, if appropriate, in the presence of an additional inert diluent, at temperatures between 0 DEG C and 100 DEG C. …