A large intestinal dissociative hard capsule comprising a capsule mainly composed of chitosan, the viscosity at 20.degree.C of a solution obtained by dissolving the chitosan in an aqueous 1% by weight acetic acid solution being not higher than 100 cps and the degree of deacetilation of the chitosan being from 60 mol% to 98 mol%, having a coated layer of a polymer soluble in a liquid having pH of at least 5 on the surface of the capsule.
