发明名称 PREPARATION OF SUBSTITUTED 8-THIOTETRAHYDROQUINOLINE DERIVATIVES
摘要 The invention relates to compounds of formula I ( I ) wherein X represents an oxygen or sulphur atom or a group of formula -NH-, -NAlk- (in which the substituent Alk represents a C1-6 alkyl group) or -NH-?-; and R1 and R2, which may be the same or different, each represents a hydrogen atom or a phenyl or naphthyl group or, together with the carbon atoms to which they are attached, represent a phenyl group, which phenyl group may optionally be substituted by a C1-6 alkyl, C1-6 alkoxy or C1-6 alkylthio group, by one or more halogen atoms, by a nitro group, by a trifluoromethyl group, or by a group of formula -CH2-?O-Alk (in which the substituent Alk represents a C1-6 alkyl group), and to pharmaceutically acceptable addition salts thereof. These compounds and their salts are useful in the treatment of allergic asthmatic conditions and bronchitis having allergic origin.
申请公布号 CA1292745(C) 申请公布日期 1991.12.03
申请号 CA19860503171 申请日期 1986.03.03
申请人 ROUSSEL-UCLAF 发明人 CLEMENTS-JEWERY, STEPHEN;KENNEWELL, PETER D.;WESTWOOD, ROBERT
分类号 A61K31/47;A61K31/505;A61P11/08;A61P37/08;C07D401/12;C07D413/12;C07D417/12 主分类号 A61K31/47
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