| 发明名称 |
CLONING, EXPRESSION AND SEQUENCING OF AN ESTER HYDROLASE GENEIN ESCHERICHIA COLI |
| 摘要 |
The invention relates to the construction of recombinant DNA molecules containing an ester hydrolase gene from Pseudomonas fluorescens and the generation of the cloned hydrolase and mutants thereof in Escherichia coli. The cloned hydrolases produced are particularly useful in the production of S-naproxen by enzymatic hydrolysis of R,S-naproxen esters in an enantiospecific fashion. |
| 申请公布号 |
EP0414247(A3) |
申请公布日期 |
1991.11.27 |
| 申请号 |
EP19900116180 |
申请日期 |
1990.08.23 |
| 申请人 |
SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED |
发明人 |
CHAN, HARDY W.;SALAZAR, FELIX H. |
| 分类号 |
C12N9/20;C12N1/21;C12N9/16;C12N15/55;C12P7/40;C12P41/00;C12R1/19;C12R1/39 |
主分类号 |
C12N9/20 |
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